White House names RFK Jr deputy Jim O'Neill as replacement CDC director

O'Neill is a former Silicon Valley tech investor and takes over the CDC at a time when some of its leading officials are deeply divided over vaccine policies.

At least three senior CDC leaders have since resigned from the agency, some citing frustration over vaccine policy and the leadership of Kennedy, also known as RFK Jr.

Among them was Chief Medical Officer Debra Houry, who warned about the "rise of misinformation" about vaccines in a letter seen by the BBC's US partner CBS News. She also argued against planned cuts to the agency's budget.

A long-time federal government scientist, Dr Monarez was nominated by President Donald Trump to lead the CDC and was confirmed in a Senate vote along party lines in July.

Her nomination followed Trump withdrawing his first pick, former Republican Congressman Dave Weldon, who had come under fire for his views on vaccines and autism.

On Wednesday, Dr Monarez's lawyers issued a statement saying that she had chosen "protecting the public over serving a political agenda".

The White House statement announcing the termination of her post said: "As her attorney's statement makes abundantly clear, Susan Monarez is not aligned with the president's agenda."

On Thursday, Kennedy told Fox & Friends on Fox News that the CDC leadership "needs to execute Trump's agenda".

The CDC, he added, "is in trouble, needs to be fixed".

The New York Times reports that she was at odds with Kennedy, external, a vaccine sceptic, over vaccine policy.

"If people are not aligned with the President's vision and the Secretary's vision to make this country healthy again, then we will gladly show them the door," White House Press Secretary Karoline Leavitt said on Thursday about the multiple exits.

The exodus at the top of one of the world's most foremost public health bodies comes as health experts voice concern over the agency's approach to immunisations since Kennedy took over.

Senator Bernie Sanders, who is the ranking member of the Senate Health, Education, Labor and Pensions (HELP) said the sacking was "reckless" and "dangerous" and called for an investigation into the firing of Dr Monarez.

Daniel Jernigan, who led the National Center for Emerging and Zoonotic Infectious Diseases, was one of those to quit citing "the current context in the department".

Head of the National Center for Immunization and Respiratory Diseases, Demetre Daskalakis, also said he was no longer able to serve "because of the ongoing weaponising of public health".

There are also reports, including by NBC News, that Dr Jennifer Layden, director of the Office of Public Health Data, Surveillance and Technology, has also resigned.